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Science | H3 Biomedicine
Science | H3 Biomedicine

Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity - ScienceDirect
Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity - ScienceDirect

SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia | Leukemia
SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia | Leukemia

FDA accepts H3 Biomedicine's IND application to start phase 1 trials for oncology drug candidate H3B-8800 | Global Pharma Update
FDA accepts H3 Biomedicine's IND application to start phase 1 trials for oncology drug candidate H3B-8800 | Global Pharma Update

h3b8800 - Twitter Search / Twitter
h3b8800 - Twitter Search / Twitter

Cancers | Free Full-Text | Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features | HTML
Cancers | Free Full-Text | Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features | HTML

Production of novel pladienolide analogues through native expression of a pathway-specific activator - Chemical Science (RSC Publishing) DOI:10.1039/D0SC01928C
Production of novel pladienolide analogues through native expression of a pathway-specific activator - Chemical Science (RSC Publishing) DOI:10.1039/D0SC01928C

PDF] Aberrant RNA Splicing in Cancer and Drug Resistance | Semantic Scholar
PDF] Aberrant RNA Splicing in Cancer and Drug Resistance | Semantic Scholar

David Steensma, MD on Twitter: "#H3B-8800 #SF3B1 inhibitor #MDS #AML Phase 1; we treated 81 patients and defined MTD as 30 mg 5d on 9 day off schedule and saw deep modulation
David Steensma, MD on Twitter: "#H3B-8800 #SF3B1 inhibitor #MDS #AML Phase 1; we treated 81 patients and defined MTD as 30 mg 5d on 9 day off schedule and saw deep modulation

Evolving therapies for lower-risk myelodysplastic syndromes | SpringerLink
Evolving therapies for lower-risk myelodysplastic syndromes | SpringerLink

Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery - ScienceDirect
Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery - ScienceDirect

IJMS | Free Full-Text | Molecular Targeted Therapy and Immunotherapy for Myelodysplastic Syndrome | HTML
IJMS | Free Full-Text | Molecular Targeted Therapy and Immunotherapy for Myelodysplastic Syndrome | HTML

Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation - ScienceDirect
Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation - ScienceDirect

Splicing factor mutant myelodysplastic syndromes: Recent advances - ScienceDirect
Splicing factor mutant myelodysplastic syndromes: Recent advances - ScienceDirect

H3B-8800 inhibits splicing of short, GC-rich introns and affects... | Download Scientific Diagram
H3B-8800 inhibits splicing of short, GC-rich introns and affects... | Download Scientific Diagram

RVT-2001 / Eisai, Roivant
RVT-2001 / Eisai, Roivant

H3 Biomedicine Publishes Comprehensive Genomic Landscape Analysis in Cell Reports Revealing Breadth, Frequency and Potential Disease-Driving Significance of Somatic Mutations in RNA Splicing Factor Genes in Multiple Types of Cancer | Business
H3 Biomedicine Publishes Comprehensive Genomic Landscape Analysis in Cell Reports Revealing Breadth, Frequency and Potential Disease-Driving Significance of Somatic Mutations in RNA Splicing Factor Genes in Multiple Types of Cancer | Business

IJMS | Free Full-Text | Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers | HTML
IJMS | Free Full-Text | Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers | HTML

Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity - ScienceDirect
Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity - ScienceDirect

Splicing modulator H3B-8800 in myeloid malignancies: phase 1 results | VJHemOnc
Splicing modulator H3B-8800 in myeloid malignancies: phase 1 results | VJHemOnc

Small Molecule of the Year – 2021 - Drug Hunter
Small Molecule of the Year – 2021 - Drug Hunter

Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B -8800 in myeloid neoplasms | Leukemia
Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B -8800 in myeloid neoplasms | Leukemia

Eisai out-licenses cancer candidate H3B-8800 to Roivant
Eisai out-licenses cancer candidate H3B-8800 to Roivant

Therapeutic approaches to treat human spliceosomal diseases. - Abstract - Europe PMC
Therapeutic approaches to treat human spliceosomal diseases. - Abstract - Europe PMC

H3B-8800 pharmacokinetics Plasma concentration in ng/mL of H3B-8800 on... | Download Scientific Diagram
H3B-8800 pharmacokinetics Plasma concentration in ng/mL of H3B-8800 on... | Download Scientific Diagram

H3B-8800 modulates splicing and selectively kills SF3B1-mutant leukemia... | Download Scientific Diagram
H3B-8800 modulates splicing and selectively kills SF3B1-mutant leukemia... | Download Scientific Diagram